Layout table for study information Study Type : Interventional (Clinical Trial) ActualEnrollment : 144 participants Allocation: Randomized Intervention Model: Crossover Assignment Intervention Model Description: The primary endpoint at 4 months following the initial treatment will utilize a parallel group study design; however, an optional crossover is offered to subjects following this time point. Masking: Triple (Participant, Investigator, Outcomes Assessor) Masking Description: All individuals will be masked to treatment with the exception of the anesthesiologist administering the procedure who will choose which probe to use: the functional or sham. Of note, this individual could not be masked to treatment since the cryoneurolysis ice ball is visualized on ultrasound; and, the practitioner would see a lack of ice ball formation for the sham probes. Primary Purpose: Treatment Official Title: Cryoanalgesia to Treat Post-Amputation Phantom Limb Pain: A Multicenter, Randomized, Double-Masked, Placebo-Controlled, Definitive Human Subjects Clinical Trial Actual Study Start Date : March 23, 2018 Actual Primary Completion Date : August 17, 2021 Actual Study Completion Date : March 17, 2022 Arms and Interventions Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Arm Intervention/treatment Active Comparator: CryoneurolysisCryoneurolysis of the femoral and sciatic nerves (or their distal counterparts) in the residual limb: The cryoneurolysis device will be triggered using 3 cycles of 2-minute gas activation separated by 1-minute defrost periods. For active probes, the nitrous oxide will be deployed to the tip where a drop in temperature to -70C will result in cryoneurolysis. Device: CryoneurolysisCryoneurolysis of the femoral and sciatic nerves (or their distal counterparts) in the residual limb: The cryoneurolysis device will be triggered using 3 cycles of 2-minute gas activation separated by 1-minute defrost periods. For active probes, the nitrous oxide will be deployed to the tip where a drop in temperature to -70C will result in cryoneurolysis.Other Name: Cryoanalgesia Sham Comparator: Sham ComparatorSham cryoneurolysis of the femoral and sciatic nerves (or their distal counterparts) in the residual limb: The cryoneurolysis device will be triggered using 3 cycles of 2-minute gas activation separated by 1-minute defrost periods. However, for sham probes, the nitrous oxide is not deployed to the tip and therefore there is no drop in temperature resulting in cryoneurolysis. Device: Sham ComparatorSham cryoneurolysis of the femoral and sciatic nerves (or their distal counterparts) in the residual limb: The cryoneurolysis device will be triggered using 3 cycles of 2-minute gas activation separated by 1-minute defrost periods. However, for sham probes, the nitrous oxide is not deployed to the tip and therefore there is no drop in temperature resulting in cryoneurolysis.Other Name: placebo, control Outcome Measures Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Primary Outcome Measures : Average daily phantom pain intensity [ Time Frame: Baseline and 4 months later (difference between the two is the primary end point) ]The difference in average daily phantom pain intensity at baseline and 4 months following the initial intervention (measured with the NRS as part of the Brief Pain Inventory) Secondary Outcome Measures : Average daily phantom pain intensity [ Time Frame: Endpoints will be evaluated at baseline and post-treatment (Day 0), Days 1 and 7; and Months 1, 2, 3, 4, and 12 [same for crossover subjects with the exception of the 12-month time point] ]The difference in average daily phantom pain intensity at baseline and various time points other than the primary at 4 months Brief Pain Inventory [ Time Frame: Endpoints will be evaluated at baseline and post-treatment (Day 0), Days 1 and 7; and Months 1, 2, 3, 4, and 12 [same for crossover subjects with the exception of the 12-month time point] ]The difference in the Brief Pain Inventory between baseline and various time points Residual limb pain (frequency and duration) [ Time Frame: Endpoints will be evaluated at baseline and post-treatment (Day 0), Days 1 and 7; and Months 1, 2, 3, 4, and 12 [same for crossover subjects with the exception of the 12-month time point] ]Pain that originates from a part of the injured limb that remains intact Patient Global Impression of Change [ Time Frame: Endpoints will be evaluated at baseline and post-treatment (Day 0), Days 1 and 7; and Months 1, 2, 3, 4, and 12 [same for crossover subjects with the exception of the 12-month time point] ]A 7-point scale of change from baseline at various time points Beck Depression Inventory [ Time Frame: At baseline, 4 months, 12 months (and 4 months following crossover for those subjects who choose to the crossover treatment) ]21-question questionnaire evaluating depression with 4-5 multiple choice responses Non-painful phantom sensations (frequency and duration) [ Time Frame: Endpoints will be evaluated at baseline and post-treatment (Day 0), Days 1 and 7; and Months 1, 2, 3, 4, and 12 [same for crossover subjects with the exception of the 12-month time point] ]Sensations that feel to emanate from the missing limb, but are not described as pain Phantom limb pain (frequency and duration) [ Time Frame: Endpoints will be evaluated at baseline and post-treatment (Day 0), Days 1 and 7; and Months 1, 2, 3, 4, and 12 [same for crossover subjects with the exception of the 12-month time point] ]Pain perceived to emanate from part of the injured limb that no longer exists Residual limb pain (NRS) [ Time Frame: Endpoints will be evaluated at baseline and post-treatment (Day 0), Days 1 and 7; and Months 1, 2, 3, 4, and 12 [same for crossover subjects with the exception of the 12-month time point] ]Pain that originates from a part of the injured limb that remains intact. Worst, least, average, and current pain levels will be recorded at each time point Eligibility CriteriaGo to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria:
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Ina sense, Murnau's film is about all of the things we worry about at 3 in themorning--cancer, war, disease, madness. It suggests these dark fears in thevery style of its visuals. Much of the film is shot in shadow. The corners ofthe screen are used more than is ordinary; characters lurk or cower there, andit's a rule of composition that tension is created when the subject of a shotis removed from the center of the frame. Murnau's special effects add to thedisquieting atmosphere: the fast motion of Orlok's servant, the disappearanceof the phantom coach, the manifestation of the count out of thin air, the useof a photographic negative to give us white trees against a black sky. 076b4e4f54
Building a Smarter Path in Web Development
The world of web development is growing rapidly, with new technologies, tools, and updates shaping how websites and applications are built. For beginners and professionals alike, staying on track requires more than just technical knowledge. It demands structured learning, smart use of online tools, and an awareness of industry standards like the Google Helpful Content Update. Alongside this, simple resources such as a word to html converter and creative web development project ideas play important roles in keeping the learning journey both effective and practical.
This blog explores how aspiring developers and content creators can combine all these elements to shape a successful career or project roadmap.
The Frontend Developer Roadmap: A Structured Guide
When entering the field of web development, the sheer number of technologies can be intimidating. A frontend developer roadmap solves this problem by offering a step-by-step guide for learning the essential skills required to build user-facing websites.
It begins with the basics of structure, styling, and interactivity, gradually expanding to frameworks, responsive design, performance optimization, and accessibility. Having such a roadmap provides clarity and prevents learners from feeling lost in an ocean of tutorials and trends.
More importantly, the frontend developer roadmap encourages consistent growth rather than rushing through flashy frameworks. By focusing first on fundamentals, developers ensure they can adapt to changing technologies while maintaining a strong foundation.
The Role of Web Development Project Ideas
Learning from a roadmap is effective, but true mastery comes from practice. This is where web development project ideas become essential. They provide opportunities to apply theory in practical ways, testing problem-solving abilities and encouraging creativity.
Project ideas can range from small experiments to larger, more structured builds. They give learners a chance to explore real-world challenges such as design consistency, user experience, and performance improvements. Moreover, each completed project strengthens a portfolio that can showcase skills to employers or clients.
By working on diverse web development project ideas, developers not only gain experience but also build confidence to face new challenges as they progress through their careers.
Efficiency Through Word to HTML Converters
While large projects capture most of the spotlight, small utilities like a word to html converter quietly enhance productivity. Many content creators draft text in word processors, and manually converting this text for web usage can be tedious. A converter solves this issue instantly, providing clean and structured output.
This tool not only saves time but also reduces the chances of errors during formatting. For businesses managing large amounts of content, it streamlines publishing. For learners, it highlights the connection between text formatting and the structure of a webpage.
Although it may seem like a simple tool, the word to html converter represents a larger principle: embracing efficiency wherever possible allows developers and content creators to focus on creativity and strategy rather than repetitive tasks.
Online Tools: The Digital Workspace
In the modern era, online tools are no longer optional—they are an integral part of web development. They enable collaboration, learning, and productivity without the barriers of complex installations or expensive software.
For beginners, online platforms provide an accessible entry point. They allow learners to experiment directly in the browser, test their knowledge, and share work easily. For professionals, online tools support teamwork, project management, and advanced testing.
These tools are also vital for remote collaboration, which has become a cornerstone of modern work culture. Whether for communication, design, testing, or deployment, they create a seamless workflow that mirrors the interconnected nature of the web itself.
The Google Helpful Content Update: Shaping Quality Standards
Beyond coding and tools, success in web development also depends on understanding how search engines evaluate websites. The Google Helpful Content Update is a significant shift in this area, emphasizing that websites should be built primarily for users rather than search engines.
This update rewards content that is original, insightful, and user-focused while penalizing sites that rely on low-value or automatically generated content. For developers and creators, this means aligning both design and content strategies with genuine helpfulness in mind.
A website built with excellent design but poor content will not perform well in rankings. Likewise, content-rich sites that ignore usability and accessibility will struggle to retain audiences. The Google Helpful Content Update reinforces the balance: both technology and content must serve the audience’s needs first.
Conclusion
Becoming a skilled web developer is a journey that requires balance: balance between learning and practice, between technology and usability, and between efficiency and creativity. A frontend developer roadmap offers clear direction, while web development project ideas bring knowledge to life. Tools like a word to html converter simplify daily tasks, and online tools open doors for collaboration and accessibility. Above all, awareness of updates like the Google Helpful Content Update ensures that developers create projects that truly serve their audiences.
Mastering Nursing Coursework: A Guide to Success in NURS FPX Assessments
Pursuing a nursing degree requires not only dedication and compassion but also a strategic approach to coursework. As students navigate their way through the RN to BSN program at Capella University, they encounter a range Nurs fpx 4040 assessment 4 of assessments designed to build essential skills in clinical practice, leadership, research, and communication. For many learners, specific assessments such as NURS FPX 4040 Assessment 4, NURS FPX 4050 Assessment 1, and others become milestones that reflect both academic progress and personal growth.
In this blog post, we will explore the significance of several key assessments in the Capella RN-to-BSN curriculum: NURS FPX 4040 Assessment 4, NURS FPX 4050 Assessment 1, NURS FPX 4060 Assessment 1, NURS FPX 4015 Assessment 4, and NURS FPX 4035 Assessment 1. Whether you're preparing to tackle these assignments or looking for insights into what each entails, this guide will provide you with the strategies and understanding needed to succeed.
Understanding the Framework of Capella’s RN-to-BSN Program
Capella University's FlexPath format offers students a self-paced, competency-based learning model. This flexibility Nurs fpx 4050 assessment 1 is ideal for working nurses who need to balance studies with professional and personal responsibilities. However, success in FlexPath requires time management, self-discipline, and a thorough understanding of what each assessment demands.
Each course includes a series of assessments that evaluate your ability to apply theoretical knowledge to real-world clinical practice. Let’s dive into the specifics.
NURS FPX 4040 Assessment 4: Evidence-Based Practice and Research
This assessment is often considered one of the more challenging yet rewarding assignments. NURS FPX 4040 Assessment 4 centers on the application of evidence-based practice (EBP) in a clinical setting. Students are typically Nurs fpx 4060 assessment 1 asked to identify a nursing issue, review the relevant literature, and design a plan for implementing EBP strategies.
Key Strategies for Success:
Start with a focused problem statement. This ensures your research remains relevant.
Use credible sources from peer-reviewed journals, preferably within the last five years.
Follow the PICO(T) framework (Population, Intervention, Comparison, Outcome, Time) to define your clinical question.
Structure your writing clearly, ensuring all sections—introduction, literature review, intervention plan, and conclusion—are cohesive.
This assessment tests your ability to connect research to practice, a skill essential in improving patient outcomes and enhancing the nursing profession.
NURS FPX 4050 Assessment 1: Leadership and Communication
NURS FPX 4050 Assessment 1 introduces students to the vital role NURS FPX 4015 Assessment 4 of leadership in nursing. The focus is often on identifying a real or hypothetical situation in a clinical setting that requires strong leadership and communication skills.
Key Concepts Covered:
Effective communication strategies
Conflict resolution
Team collaboration
Ethical decision-making
Tips for Success:
Reflect on your own experiences in a healthcare setting and how leadership influenced outcomes.
Use theoretical frameworks like transformational or servant leadership models to support your analysis.
Provide examples of how communication either improved or hindered the situation.
Always include cultural competence and patient-centered care in your discussion.
By mastering this assessment, you’ll be better equipped to lead interdisciplinary teams and foster a collaborative care environment.
NURS FPX 4060 Assessment 1: Coordinated Care
NURS FPX 4060 Assessment 1 focuses on the coordination of care, particularly for vulnerable populations. This assessment typically requires the creation of a care coordination plan, highlighting how to manage patients across various settings and with input from multiple healthcare professionals.
What You’ll Need to Demonstrate:
Understanding of social determinants of health
Familiarity with interdisciplinary collaboration
Ability to identify community resources
Communication with patients, families, and care teams
Advice for Completion:
Choose a realistic patient profile, such as a senior with chronic illnesses or a child with complex care needs.
Explore community health initiatives that could support your care plan.
Emphasize holistic care—mental, physical, and social well-being.
This assignment underscores the nurse’s role as a patient advocate and care coordinator, both critical in modern nursing.
NURS FPX 4015 Assessment 4: Pathophysiology and Nursing Practice
The NURS FPX 4015 Assessment 4 requires a deep dive into a NURS FPX 4035 Assessment 1 specific disease process and its impact on patient care. This assignment typically includes an in-depth case study and an exploration of the pathophysiological processes involved.
What to Focus On:
Accurate pathophysiological explanations of the disease
Clinical manifestations and diagnostic tests
Treatment modalities and nursing interventions
Patient education and preventive strategies
Study Tips:
Select a disease that you are interested in or have experience treating.
Use scholarly sources for the most up-to-date clinical guidelines.
Explain medical terminology in layman's terms when discussing patient education.
This assessment is a great opportunity to demonstrate how knowledge of pathophysiology informs safe, effective nursing care.
NURS FPX 4035 Assessment 1: Health Promotion and Disease Prevention
Finally, NURS FPX 4035 Assessment 1 introduces students to the foundational concepts of community and public health. It emphasizes proactive strategies nurses can take to promote health and prevent disease, both at the individual and population levels.
Key Topics Often Included:
Preventive screenings and immunizations
Health education campaigns
Cultural sensitivity in care
Public health models (e.g., Health Belief Model)
Strategies for Success:
Identify a specific population or community health issue, such as obesity in adolescents or smoking cessation.
Analyze contributing factors including socioeconomic status, environment, and access to healthcare.
Recommend realistic and evidence-based health promotion strategies.
This assessment allows you to shift from bedside nursing to a broader public health lens, promoting wellness and prevention on a larger scale.
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